电子邮箱：menglu@pku.edu.cn

个人主页：http://lumenglab.com 

教育经历：

2011年 – 2015年    博士 生物技术                 剑桥大学 

2009年 – 2011年    本科 化学工程               爱丁堡大学

2007年 – 2009年    本科 材料控制与成型   华南理工大学

学术简历 ：

2024年1月-至今      研究员   P.I.   博士生导师                                                    临床医学高等研究院

2022年-2023年      高级副研究员  P.I.   博士生导师     化工与生物技术系           剑桥大学

2016年-2022年      副研究员                                      化工与生物技术系            剑桥大学

研究领域：

1.多模态生物模型，

2.神经元网络的结构和动力学

3.计算机视觉技术在生物医学，尤其是神经退行性病中的应用

获得荣誉：

1.Journal of Biological Chemistry 2019年度代表分子生物物理论文 2019

2.ICTP Travel Grant 国际理论物理研究中心 2018

3.uK-Korea Neuroscience Consortium Travel Grant 英韩神经科学论坛  2018

近5年代表性论文：

1.Lu M, Christensen CN, Weber J, Konno T, L？ubli N, Scherer K, Lapkin A, Lio P, Avezov E, Kaminski Schierle GS, Kaminski CF. ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology. Nature Methods. 2023 Mar 30:1-1.  

2.Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Kaminski Schierle GS, Kaminski CF. 2020. The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes. Science Advances. 16;6(51): eabc7209.  

3.Lu M, Williamson, N, Mishra, A., Michel, C.H, Kaminski, C.F., Tunnacliffe, A. and Schierle, G.S.K,. Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging. J. Biol. Chem., 2019, 294(5), pp.1478-1487.

• 被选为2019年度代表分子生物物理论文 (representative paper of “Molecular Biophysics” of J. Biol. Chem in the year of 2019).
• 被选为封面文章和编辑推荐文章 (Cover story, designated as “Editors’picks” )
• J.B.C. 特别评论文章予以重点推荐: Capturing Aβ aggregation in the cell” by Francesco Bemporad, Cristina Cecchi and Fabrizio Chiti in J. Biol. Chem.)

评论节选：

“For the first time, the acceleration in Aβ42 aggregation induced by the Arctic mutation was monitored in cells, revealing a number of distinct morphologies that form sequentially. This approach will help discriminate the impacts of mutations on amyloid protein processing, Aβ aggregation propensity, and other mechanistic outcomes.”

 ——“Capturing Aβ aggregation in the cell” by Francesco Bemporad, Cristina Cecchi and Fabrizio Chiti, J. Biol. Chem.

4.Lu M, Ward E, van Tartwijk FW, Kaminski CF. 2021. Advances in the study of organelle interactions and their role in neurodegenerative diseases enabled by super-resolution microscopy. Neurobiology of Disease, p.105475.

5.Lu M, Mishra A, Boschetti C, Kaminski CF, Huang Z, Tunnacliffe A, Kaminski Schierle GS. 2021. Synthetic peptides derived from sea cucumber alleviate oxidative stress in neuroblastoma cells and improve survival in Caenorhabditis elegans exposed to neurotoxic paraquat. Oxidative Medicine and Cellular Longevity. 8842926.

6.Lu M, Kaminski CF, Kaminski Schierle GS. 2020. Advanced fluorescence imaging of in situ protein aggregation. Physical Biology. Jan 8.