电子邮箱：gaoweiping@hsc.pku.edu.cn
实验室网页：http://openwetware.org/wiki/Gao_lab
教育经历:
2000.09 - 2004.06 北京大学 高分子化学与物理专业博士
1993.09 - 2000.06 青岛化工学院 高分子工程专业本科与硕士
学术简历 :
2019.01 - 至今 北京大学跨学部生物医学工程系研究员，博士生导师
2011.10 - 2018.11 清华大学医学院生物医学工程系研究员，博士生导师
2007.05 - 2011.08 美国杜克大学生物医学工程系博士后
2005.05 - 2007.04 日本京都大学化学研究所博士后
主持、参与项目研究方向：
研究领域: 生物材料；药物递送
研究方向: 蛋白质工程；蛋白质-药物偶联物；蛋白质-高分子偶联物；高分子-药物偶联物；药物递送；靶向蛋白降解；肿瘤诊疗；传染病治疗；免疫治疗；代谢性疾病治疗；自身免疫与炎症性疾病治疗；神经退行性疾病治疗
获得荣誉：
2023年 北京大学第六届产学研项目合作先进个人
2022年 中国致公党北京市委员会社会服务暨专项民主监督工作先进个人
2019年 清华大学优秀博士学位论文指导教师奖
2017年 清华大学优秀博士学位论文一等奖导师奖
2016年 拜耳研究员奖
2012年 杨森研究员奖
2007年 中国科协优秀学术论文奖
1996年 化工部科技兴化奖
近5年代表性论文：
1.Sanke Zhang, Yuanzi Sun, Fan Zhang, Like Gong, Weiping Gao*. An ultra-long-acting L-asparaginase synergizes with an immune checkpoint inhibitor in starvation-immunotherapy of metastatic solid tumors. Biomaterials 2025, 312, 122740
2.Yilin Li, Yuanzi Sun, Fan Zhang, Qiongqiong Yao, Like Gong, Yongjun Wang*, Weiping Gao*. Synergic Chemoimmunotherapy of Cervical Cancer by Combining Cisplatin with Thermosensitive Polypeptide Fused Interferon Alpha. Adv. Ther. 2024, 2400098
3.Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Yinghao zheng, Weiping Gao*, Xunbin Wei*. Hypoxia Reversion by Low-Immunogenic Ultra-Acid-Sensitive Comicelles of Protein-Polymer Conjugates Sensitizes Tumors to Photodynamic Therapy. J. Am. Chem. Soc. 2024, 146, 7543？7554
4.Zhaoying Yang, Qiongqiong Yao, Like Gong, Fan Zhang, Jiawei Sun, Yuanzi Sun, Weiping Gao*. A Superlong-acting Growth Hormone-polypeptide Fusion for Growth Hormone Deficiency Treatment. Adv. Healthcare Mater. 2023, 2302507.
5. Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei*, Weiping Gao*. Spatiotemporally-programmed dual-acid-sensitive nanoworms of albumin-poly(tertiary amine)-doxorubicin conjugates for enhanced cancer chemotherapy. Adv. Healthcare Mater. 2023, 2301890.
6. Xinyu Liu, Weiping Gao*. The development and application of site-specific In situ controlled polymerization (SICP). Acta Polym. Sin. 2023, 54, 1395-1408.
7. Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao*. Thermoresponsive polypeptide fused L-asparaginase with mitigated immunogenicity and enhanced e？cacy in treating hematologic malignancies. Adv. Sci. 2023, 2300469.
8.Jiawei Sun, Jianwen Guo, Longshuai Zhang, Like Gong, Yuanzi Sun, Xuliang Deng, Weiping Gao* Active-targeting long-acting protein-glycopolymer conjugates for selective cancer therapy. J. Control. Release 2023, 356, 175-184.
9.Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng*，Weiping Gao*,Thermo-pH-sensitive polymer conjugated glucose oxidase for tumour-selective starvation-oxidation-immune therapy. Adv. Mater. 2023, adma.202209765
10.Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng, Weiping Gao*. Hypoxia-triggered bioreduction of poly(N-oxide)-drug conjugates enhances tumour penetration and antitumour efficacy. J. Am. Chem. Soc. 2023, 145, 1707-1713.
11.Xiang Zhang, Fei Duan, Fan Zhang, Xuliang Deng, Weiping Gao* Thermosensitive polymer conjugated prodrug-activating enzyme with enhanced tumor retention and antitumor effcacy. Biomacromolecules 2022, 23，4834-4840.
12.Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang*, Xuliang Deng*, Cyrille Boyer*, Weiping Gao*. N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance. Nano Lett. 2022, 22, 8294-8303.
13. Like Gong, Zhaoying Yang, Fan Zhang, Weiping Gao*. Cytokine conjugates to elastin-like polypeptides. Adv. Drug Deliver. Rev. 2022, 190, 114541.
14.Fei Duan, Wei Jin, Tong Zhang, Fan Zhang, Like Gong, Xinyu Liu, Xuliang Deng*, and Weiping Gao*. Self-Activated Cascade Biocatalysis of Glucose Oxidase-Polycation-Iron Nanoconjugates Augments Cancer Immunotherapy. ACS Appl. Mater. Interfaces 2022, 14, 32823-32835.
15.Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang*, Weiping Gao*. Peptide/protein-based macrocycles: from biological synthesis to biomedical applications. RSC Chem. Biol., 2022, 3, 815-829.
16.Zhaoying Yang, Fan Zhang, Jianwen Guo, Weiping Gao*. Biosynthesis of Elastin-Like Polypeptides and their applications in drug delivery. Synth. Biol. J., 2022, 3(4): 728-747.
17. Xinyu Liu, Weiping Gao*. Precision conjugation：an emerging tool for generating protein-polymer conjugates. Angew. Chem. Int. Ed. 2021, 60,11024-11035.
18. Jiawei Sun, Xinyu Liu, Jianwen Guo, Wenguo Zhao, Weiping Gao*. Pyridine-2,6-dicarboxaldehyde enabled N-terminal in situ growth of polymer-interferon alpha conjugate with significantly improved pharmacokinetics and in vivo bioactivity. ACS Appl. Mater. Interfaces 2021, 13，88-96.
19.Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang, Weiping Gao*. Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy. Biomaterials 2021, 264, 120447.
20.Zhuoran Wang, Jianwen Guo, Xinyu Liu, Jiawei Sun, Weiping Gao*. Temperature-Triggered Micellization of Interferon Alpha-Diblock Copolypeptide Conjugate with Enhanced Stability and Pharmacology. J. Control. Release 2020, 328, 444-453.
21.Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao*. Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology. Biomaterials 2020, 250, 120073.
22.Chi-Wei Chiang, Xinyu Liu, Jiawei Sun, Jianwen Guo, Lei Tao, Weiping Gao*. Polymerization-induced coassembly of enzyme–polymer conjugates into comicelles with tunable and enhanced cascade activity. Nano Letters 2020, 20, 1383-1387.
23.Rongzan Lin, Xinghui Yan, Hanjun Hao, Weiping Gao*, Ran Liu*. Introducing temperature-controlled phase transition elastin-like polypeptides to transient electronics: realization of proactive biotriggered electronics with local transience. ACS Appl. Mater. Interfaces 2019, 11, 46490-46496.
24.Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 6，1900586.
25.Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao*. In situ growth of a cationic polymer from the N-terminus of glucose oxidase to regulate H2O2 generation for cancer starvation and H2O2 therapy. ACS Appl. Mater. Interfaces 2019, 11, 9756-9762.
26.Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao* . One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112.
27.Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479.
28.Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon -block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.
29.Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645.
30.Xinyu Liu, Jiawei Sun, Weiping Gao*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434.
31.Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao*. Temperature-responsive polymer conjugation of interferon- enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.
32.Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo*, Weiping Gao*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75.
33.Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9，23528-23535.
34.Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460.
35.Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028.
36.Guilin Wang, Jin Hu, Weiping Gao*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60，563-570.
37.Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77.
38.Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92.
39.Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457.
40.Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.
41.Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao*. Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification. Biomaterials 2015, 64, 2-9.
42.Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao* Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects. Chem. Commun. 2015, 51, 11405-11408.
43.Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao*. Synthesis of well-defined protein-polymer conjugates for biomedicine. Polymer 2015, 66, A1-A10.
44.Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao*. Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention. Biomaterials 2015, 47, 13-19.
45.Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti*. In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide. Polym. Chem. 2011, 2,1561-1566.
46.Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti*. In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437.
47.Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti*. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236.
48.Weiping Gao, Yu Bai, Erqiang Chen*, Zichen Li*, Bingyong Han, Wantai Yang, Qifeng Zhou*. Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution. Macromolecules 2006, 39, 4894-4898.