电子邮箱：gaoweiping@hsc.pku.edu.cn
实验室网页：http://openwetware.org/wiki/Gao_lab
教育经历:
2000.09 - 2004.06 北京大学 高分子化学与物理专业博士
1993.09 - 2000.06 青岛化工学院 高分子工程专业本科与硕士
学术简历 :
2019.01 - 至今 北京大学跨学部生物医学工程系研究员，博士生导师
2011.10 - 2018.11 清华大学医学院生物医学工程系研究员，博士生导师
2007.05 - 2011.08 美国杜克大学生物医学工程系博士后
2005.05 - 2007.04 日本京都大学化学研究所博士后
主持、参与项目研究方向：
研究领域: 生物偶联；生物材料
研究方向: 蛋白质-高分子偶联物；蛋白质-药物偶联物；抗体-高分子-药物偶联物；药物递送；分子影像；再生医学；肿瘤诊疗；传染病诊疗；免疫治疗；靶向蛋白降解
获得荣誉：
2019年 清华大学优秀博士学位论文指导教师奖
2017年 清华大学优秀博士学位论文一等奖导师奖
2016年 拜耳研究员奖
2012年 杨森研究员奖
2007年 中国科协优秀学术论文奖
1996年 化工部科技兴化奖
近5年代表性论文：
1.Zhaoying Yang, Qiongqiong Yao, Like Gong, Fan Zhang, Jiawei Sun, Yuanzi Sun, Weiping Gao*. A Superlong-acting Growth Hormone-polypeptide Fusion for Growth Hormone Deficiency Treatment. Adv. Healthcare Mater. 2023, 2302507.
2. Wenchao Huang, Longshuai Zhang, Jiawei Sun, Yuanzi Sun, Like Gong, Sisi Ge, Xunbin Wei*, Weiping Gao*. Spatiotemporally-programmed dual-acid-sensitive nanoworms of albumin-poly(tertiary amine)-doxorubicin conjugates for enhanced cancer chemotherapy. Adv. Healthcare Mater. 2023, 2301890.
3. Xinyu Liu, Weiping Gao*. The development and application of site-specific In situ controlled polymerization (SICP). Acta Polym. Sin. 2023, 54, 1395-1408.
4. Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao*. Thermoresponsive polypeptide fused L-asparaginase with mitigated immunogenicity and enhanced e？cacy in treating hematologic malignancies. Adv. Sci. 2023, 2300469.
5.Jiawei Sun, Jianwen Guo, Longshuai Zhang, Like Gong, Yuanzi Sun, Xuliang Deng, Weiping Gao* Active-targeting long-acting protein-glycopolymer conjugates for selective cancer therapy. J. Control. Release 2023, 356, 175-184.
6.Fei Duan, Wei Jin, Tong Zhang, Yuanzi Sun, Xuliang Deng*，Weiping Gao*,Thermo-pH-sensitive polymer conjugated glucose oxidase for tumour-selective starvation-oxidation-immune therapy. Adv. Mater. 2023, adma.202209765
7.Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng, Weiping Gao*. Hypoxia-triggered bioreduction of poly(N-oxide)-drug conjugates enhances tumour penetration and antitumour efficacy. J. Am. Chem. Soc. 2023, 145, 1707-1713.
8.Xiang Zhang, Fei Duan, Fan Zhang, Xuliang Deng, Weiping Gao* Thermosensitive polymer conjugated prodrug-activating enzyme with enhanced tumor retention and antitumor effcacy. Biomacromolecules 2022, 23，4834-4840.
9.Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang*, Xuliang Deng*, Cyrille Boyer*, Weiping Gao*. N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance. Nano Lett. 2022, 22, 8294-8303.
10. Like Gong, Zhaoying Yang, Fan Zhang, Weiping Gao*. Cytokine conjugates to elastin-like polypeptides. Adv. Drug Deliver. Rev. 2022, 190, 114541.
11.Fei Duan, Wei Jin, Tong Zhang, Fan Zhang, Like Gong, Xinyu Liu, Xuliang Deng*, and Weiping Gao*. Self-Activated Cascade Biocatalysis of Glucose Oxidase-Polycation-Iron Nanoconjugates Augments Cancer Immunotherapy. ACS Appl. Mater. Interfaces 2022, 14, 32823-32835.
12.Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang*, Weiping Gao*. Peptide/protein-based macrocycles: from biological synthesis to biomedical applications. RSC Chem. Biol., 2022, 3, 815-829.
13.Zhaoying Yang, Fan Zhang, Jianwen Guo, Weiping Gao*. Biosynthesis of Elastin-Like Polypeptides and their applications in drug delivery. Synth. Biol. J., 2022, 3(4): 728-747.
14. Xinyu Liu, Weiping Gao*. Precision conjugation：an emerging tool for generating protein-polymer conjugates. Angew. Chem. Int. Ed. 2021, 60,11024-11035.
15. Jiawei Sun, Xinyu Liu, Jianwen Guo, Wenguo Zhao, Weiping Gao*. Pyridine-2,6-dicarboxaldehyde enabled N-terminal in situ growth of polymer-interferon alpha conjugate with significantly improved pharmacokinetics and in vivo bioactivity. ACS Appl. Mater. Interfaces 2021, 13，88-96.
16.Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang, Weiping Gao*. Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy. Biomaterials 2021, 264, 120447.
17.Zhuoran Wang, Jianwen Guo, Xinyu Liu, Jiawei Sun, Weiping Gao*. Temperature-Triggered Micellization of Interferon Alpha-Diblock Copolypeptide Conjugate with Enhanced Stability and Pharmacology. J. Control. Release 2020, 328, 444-453.
18.Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao*. Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology. Biomaterials 2020, 250, 120073.
19.Chi-Wei Chiang, Xinyu Liu, Jiawei Sun, Jianwen Guo, Lei Tao, Weiping Gao*. Polymerization-induced coassembly of enzyme–polymer conjugates into comicelles with tunable and enhanced cascade activity. Nano Letters 2020, 20, 1383-1387.
20.Rongzan Lin, Xinghui Yan, Hanjun Hao, Weiping Gao*, Ran Liu*. Introducing temperature-controlled phase transition elastin-like polypeptides to transient electronics: realization of proactive biotriggered electronics with local transience. ACS Appl. Mater. Interfaces 2019, 11, 46490-46496.
21.Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 6，1900586.
22.Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao*. In situ growth of a cationic polymer from the N-terminus of glucose oxidase to regulate H2O2 generation for cancer starvation and H2O2 therapy. ACS Appl. Mater. Interfaces 2019, 11, 9756-9762.
23.Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao* . One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112.
24.Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479.
25.Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon -block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.
26.Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645.
27.Xinyu Liu, Jiawei Sun, Weiping Gao*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434.
28.Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao*. Temperature-responsive polymer conjugation of interferon- enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.
29.Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo*, Weiping Gao*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75.
30.Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9，23528-23535.
31.Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460.
32.Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028.
33.Guilin Wang, Jin Hu, Weiping Gao*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60，563-570.
34.Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77.
35.Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92.
36.Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457.
37.Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.
38.Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao*. Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification. Biomaterials 2015, 64, 2-9.
39.Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao* Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects. Chem. Commun. 2015, 51, 11405-11408.
40.Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao*. Synthesis of well-defined protein-polymer conjugates for biomedicine. Polymer 2015, 66, A1-A10.
41.Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao*. Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention. Biomaterials 2015, 47, 13-19.
42.Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti*. In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide. Polym. Chem. 2011, 2,1561-1566.
43.Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti*. In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437.
44.Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti*. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236.
45.Weiping Gao, Yu Bai, Erqiang Chen*, Zichen Li*, Bingyong Han, Wantai Yang, Qifeng Zhou*. Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution. Macromolecules 2006, 39, 4894-4898.