高卫平

电子邮箱:gaoweiping@hsc.pku.edu.cn

实验室网页:http://openwetware.org/wiki/Gao_lab

 


教育经历:

 

2000.09 - 2004.06  北京大学 高分子化学与物理专业博士

1993.09 - 2000.06  青岛化工学院 高分子工程专业本科与硕士

 

学术简历 :

 

2019.01 - 至今      北京大学跨学部生物医学工程系研究员,博士生导师

2011.10 - 2018.11  清华大学医学院生物医学工程系研究员,博士生导师

2007.05 - 2011.08  美国杜克大学生物医学工程系博士后

2005.05 - 2007.04  日本京都大学化学研究所博士后

 

主持、参与项目研究方向:

 

研究领域: 生物材料;生物治疗

研究方向: 大分子生物材料;蛋白质工程;重组蛋白质材料;重组蛋白质药物蛋白质-高分子偶联物;蛋白质-药物偶联物;重组多肽-药物偶联物;药物与生物大分子递送;肿瘤影像与治疗;免疫治疗;基因编辑与治疗

 

获得荣誉:

 

 2019年   清华大学优秀博士学位论文指导教师奖

2017   清华大学优秀博士学位论文一等奖导师奖

2016   拜耳研究员奖

2012   杨森研究员奖

2007   中国科协优秀学术论文奖

1996   化工部科技兴化奖

 

5年代表性论文:

 

1.  Xinyu Liu, Weiping Gao* Precision conjugation:an emerging tool for generating protein-polymer conjugates. Angew. Chem. Int. Ed. 2021, 60, 2-14.

2. Jiawei Sun, Xinyu Liu, Jianwen Guo, Wenguo Zhao, Weiping Gao*. Pyridine-2,6-dicarboxaldehyde enabled N-terminal in situ growth of polymer-interferon alpha conjugate with significantly improved pharmacokinetics and in vivo bioactivity. ACS Appl. Mater. Interfaces 2021, 1388-96.

3.Ping Liang, Guihuai Wang, Xinyu Liu, Zhuoran Wang, Jing Wang, Weiping Gao*. Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy. Biomaterials 2021264, 120447.

4.Zhuoran Wang, Jianwen Guo, Xinyu Liu, Jiawei Sun, Weiping Gao*. Temperature-Triggered Micellization of Interferon Alpha-Diblock Copolypeptide Conjugate with Enhanced Stability and Pharmacology. J. Control. Release 2020, 328, 444-453.

5.Jianwen Guo, Jiawei Sun, Xinyu Liu, Zhuoran Wang, Weiping Gao*. Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology. Biomaterials 2020, 250, 120073.

6.Chi-Wei Chiang, Xinyu Liu, Jiawei Sun, Jianwen Guo, Lei Tao, Weiping Gao*. Polymerization-induced coassembly of enzyme–polymer conjugates into comicelles with tunable and enhanced cascade activity. Nano Letters 2020, 20, 1383-1387.

7.Rongzan Lin, Xinghui Yan, Hanjun Hao, Weiping Gao*, Ran Liu*. Introducing temperature-controlled phase transition elastin-like polypeptides to transient electronics: realization of proactive biotriggered electronics with local transience.  ACS Appl. Mater. Interfaces 2019, 11, 46490-46496.

8.Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019,  6,1900586.

9.Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao*. In situ growth of a cationic polymer from the N-terminus of glucose oxidase to regulate H2O2 generation for cancer starvation and H2O2 therapy. ACS Appl. Mater. Interfaces 2019, 11, 9756-9762.

10.Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao* . One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112.

11.Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479.

12.Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon -block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438.

13.Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645.

14.Xinyu Liu, Jiawei Sun, Weiping Gao*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434.

15.Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao*. Temperature-responsive polymer conjugation of interferon- enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.

16.Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo*, Weiping Gao*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75.

17.Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9,23528-23535.

18.Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460.

19.Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028.

20.Guilin Wang, Jin Hu, Weiping Gao*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60,563-570.

21.Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77.

22.Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92.

23.Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457.

24.Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324.

25.Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao*. Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification. Biomaterials 2015, 64, 2-9.

26.Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao* Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects. Chem. Commun. 2015, 51, 11405-11408.

27.Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao*. Synthesis of well-defined protein-polymer conjugates for biomedicine. Polymer 2015, 66, A1-A10.

28.Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao*. Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention. Biomaterials 2015, 47, 13-19.

29.Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti*. In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide. Polym. Chem. 2011, 2,1561-1566.

30.Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti*. In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437.

31.Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti*. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236.

32.Weiping Gao, Yu Bai, Erqiang Chen*, Zichen Li*, Bingyong Han, Wantai Yang, Qifeng   Zhou*. Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution.  Macromolecules 2006, 39, 4894-4898.