教育经历:
博士 药理学 美国凯斯西储大学
硕士 解剖学 新加坡国立大学
本科 临床医学 北京大学医学部
学术简历 :
北京大学跨学部生物医学工程系，双聘教授，博士生导师
研究领域：
以骨分子开关Osx为轴心研究干细胞与骨再生医学，包括三个方面:
1) 骨科基础研究：骨形成的基因调控，干细胞定向分化为成骨细胞的分子机制
2) 转化医学研究：骨质疏松/关节炎/骨坏死/异位骨化以及骨肿瘤等发病机制；生物材料应用
3) 创新药物研发：通过高端筛选法研发具有自主知识产权的创新药物治疗骨质疏松
获得荣誉：
近5年代表性论文：
1.Yang X, Chen Z, Meng X, Sun C, Li M, Shu L, Fan D, Fan T, Huang A, Zhang C *. (2018) Angiopoietin-2 promotes osteogenic differentiation of thoracic ligamentum flavum cells via modulating the Notch signaling pathway. PLoS One 13(12): e0209300.
2.Yang X, Qu X, Meng X, Li M, Fan D, Fan T, Huang A, Chen Z, Zhang C *. (2018) MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1. Int J Biol Sci 14(11):1457-1465
3.Zhang C *, Chen Z, Meng X, Li M, Zhang L, Huang A. (2017) The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum. PLoS One 12(6): e0178986.
4.Yang Y, Huang YH, Zhang L, Zhang C *. (2016) Transcriptional regulation of bone sialoprotein gene expression by Osx. Biochem Biophys Res Commun 476(4):574–579
5.Xing Y, Wang RX, Chen D, Mao JP, Shi R; Wu Z, Kang J, Tian W, Zhang C *. (2015) Cox2 is involved in hypoxia-induced TNF-α expression in osteoblast. Sci. Rep. 5:10020
6.Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, Zhang C *. (2012) Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in Osteoblasts. J Biol Chem. 287(3): 1671-1678.
7.Tang W, Li Y, Osimiri L, Zhang C *. (2011) Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation. J Biol Chem. 286(38):32995-33002.
8.Zhang C, Cho K, Huang YH, Lyons JP, Zhou X, Sinha K, McCrea PD and de Crombrugghe B. (2008) Inhibition of Wnt Signaling by the Osteoblast-Specific Transcription Factor Osterix. Proc. Nat. Acad. Sci. USA (PNAS) 105(19): 6936-6941.
9.Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, and MacDonald PN. (2003) Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 278(37):35325-35336.
10.Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN. (2001) Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. J Biol Chem. 276(44):40614-40620.