电子邮箱：Shaokun_shu@bjmu.edu.cn
 

教育经历:

2003    本科，生物工程，北京理工大学

2010    博士，分子肿瘤学，美国南佛罗里达大学

学术简历 :

2019.9–至今    北京大学跨学部生物医学工程系，助理教授，博士生导师
2011.8–2019.8  哈佛医学院Dana-Farber 肿瘤研究中心，博士后
2011.1–2011.8  美国南佛罗里达大学，博士后
2003.8–2005.8  中科院基因组所，研究助理

研究领域：

肿瘤表观遗传学；靶向治疗；肿瘤抗药性；联合用药

获得荣誉：

2017, Jon Shevell Young Scientist Scholarship

2016, Jon Shevell Young Scientist Scholarship

2015, AACR Breast Cancer training award

2010, Travel award and oral presentation, American Association for Cancer Research, Mini-symposium

近5年代表性论文：

1.Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K. Response and resistance to BET bromodomain inhibitors in triple negative breast cancer. Nature. 2016; 529: 413–417.

2.Shu S, Polyak K. BET Bromodomain Proteins as Cancer Therapeutic Targets. Cold Spring Harbor Symposia on Quantitative Biology. 2016;81:123-129.

3.Janiszewska M, Tabassum DP, Casta？o Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Del Alcazar CG, Ale？kovi？ M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K. Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. Nat Cell Biol. 2019 Jul;21(7):879-888.

4.Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K. TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Reports. 2018 Oct 30;25(5):1255-1267

5.Marusyk A, Tabassum DP, Janiszewska M, Place AE, Trinh A, Rozhok AI, Pyne S, Guerriero JL, Shu S, Ekram M, Ishkin A, Cahill DP, Nikolsky Y, Chan TA, Rimawi MF, Hilsenbeck S, Schiff R, Osborne KC, Letai A, Polyak K. Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes. Cancer Research. 2016 Nov 15;76(22):6495-6506.

6.Guo JP, Shu SK, He L, Lee YC, Kruk PA, Grenman S, Nicosia SV, Coppola D, Cheng JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol. 2009;175:324-33.