电子邮箱：laib@bjmu.edu.cn

教育经历:

2003/09 – 2008/07 吉林大学 数学与应用数学 本科

2008/09 – 2013/07 北京大学 生物医学工程 博士

学术简历 :

2014/01 – 2016/06 NIH/NIDDK 博士后

2016/07 – 2019/12 NIH/NHLBI 博士后

 2020/01-至今        北京大学跨学部生物医学工程系

研究领域：

生物信息学/计算生物学；开发与应用高通量测序技术及数据分析方法研究表观遗传机制；单细胞组学；免疫T细胞分化、癌症相关的表观遗传与基因调控机制

获得荣誉：

 NIH/NHLBI Orloff Science Award

近5年代表性论文:

1.Lai B, Gao W, Cui K, Xie W, Tang Q, Jin W, Hu G, Ni B, Zhao K. (2018) Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing. Nature, 562:281-285.

2.Lai B*, Tang Q*, Jin W*, Hu G*, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. (2018) Trac-looping measures genome structure and chromatin accessibility. Nat Methods, 15(9):741-747.

3.Lai B*, Lee JE*, Jang Y, Wang L, Peng W, Ge K. (2017) MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res, 45(11):6388-6403.

4.Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A. (2019) The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat Immunol, doi: 10.1038/s41590-019-0445-7.

5.Lee JE, Schmidt H, Lai B, Ge K. (2019) Transcriptional and Epigenomic Regulation of Adipogenesis. Mol Cell Biol, DOI: 10.1128/MCB.00601-18.

6.Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K. (2017) Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nat Commun, 8(1):2217.

7.Wang C, Lee JE, Lai B, Macfarian TS, Xu S, Zhuang L, Liu C, Peng W, Ge K. (2016) Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition. Proc Natl Acad Sci U S A, 113:11871-11876.

1）Lai B, Gao W, Cui K, Xie W, Tang Q, Jin W, Hu G, Ni B, Zhao K. (2018) Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing. Nature, 562:281-285.

（2）Lai B*, Tang Q*, Jin W*, Hu G*, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. (2018) Trac-looping measures genome structure and chromatin accessibility. Nat Methods, 15(9):741-747.

（3）Lai B*, Lee JE*, Jang Y, Wang L, Peng W, Ge K. (2017) MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis. Nucleic Acids Res, 45(11):6388-6403.

 （4）Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A. (2019) The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat Immunol, doi: 10.1038/s41590-019-0445-7.

（5） Lee JE, Schmidt H, Lai B, Ge K. (2019) Transcriptional and Epigenomic Regulation of Adipogenesis. Mol Cell Biol, DOI: 10.1128/MCB.00601-18.

（6）Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K. (2017) Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nat Commun, 8(1):2217.

（7） Wang C, Lee JE, Lai B, Macfarian TS, Xu S, Zhuang L, Liu C, Peng W, Ge K. (2016) Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition. Proc Natl Acad Sci U S A, 113:11871-11876.